apalutamide will reduce the level or result of diazepam by affecting hepatic enzyme CYP2C19 metabolism. Prevent or Use Alternate Drug. Coadministration of apalutamide, a strong CYP2C19 inducer, with medicine that are CYP2C19 substrates may result in lower exposure to those drugs.I had a Seizure Action Strategy which i trained All those about me to